Piekarska T
Pol J Pharmacol Pharm. 1981 Jan-Feb;33(1):43-8.
Experimental cardiomyopathy was produced by isoprenaline (2 x 80 mg/kg sc daily for 2 days). The degree of myocardial damage was evaluated histopathologically. In the damaged cardiac muscle the incorporation of 14C-adenine was impaired, the adenylate cyclase activity was diminished and the total contents of cAMP and 14C-cAMP formed from intracellular 14C-adenine metabolism were reduced. No significant changes in the activity of phosphodiesterase were found. This indicates that cAMP synthesis is impaired as a result of decreased utilization of the ATP pool formed from exogenous adenine in the cardiac muscle damaged by isoprenaline.
通过注射异丙肾上腺素（每天皮下注射2次，每次80mg/kg，连续2天）诱导实验性心肌病。通过组织病理学评估心肌损伤程度。在受损心肌中，14C-腺嘌呤的掺入受损，腺苷酸环化酶活性降低，由细胞内14C-腺嘌呤代谢形成的cAMP和14C-cAMP的总含量减少。未发现磷酸二酯酶活性有显著变化。这表明，在异丙肾上腺素损伤的心肌中，由于外源性腺嘌呤形成的ATP池利用率降低，导致cAMP合成受损。
