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[甲状腺素和肾上腺色素对心肌腺苷酸环化酶活性及环磷酸腺苷水平的非肾上腺素能受体依赖性作用]

[Adrenoreceptor-independent effect of thyroxine and adrenoxyl on myocardial adenyl cyclase activity and cAMP levels].

作者信息

Tapbergenov S O, Koptelov V A

出版信息

Biull Eksp Biol Med. 1981 Apr;91(4):427-9.

PMID:6266548
Abstract

A study was made of the effect of different concentrations of noradrenaline, adrenaline, adrenoxyl (stabilized adrenochrome) and thyroxin on the adenylate cyclase activity and cAMP content in the myocardium of intact animals and in neurogenous affections of the myocardium. It was shown that the content of cAMP in the myocardium drops in neurogenous affections and that thyroxin or adrenoxyl in combination with beta-adrenoblockers (propranolol) might be used for the recovery of the cAMP content and adenylate cyclase activity.

摘要

研究了不同浓度的去甲肾上腺素、肾上腺素、肾上腺色素(稳定化的肾上腺色素)和甲状腺素对完整动物心肌以及心肌神经源性病变中腺苷酸环化酶活性和环磷酸腺苷(cAMP)含量的影响。结果表明,在神经源性病变中,心肌中的cAMP含量下降,甲状腺素或肾上腺色素与β-肾上腺素能阻滞剂(普萘洛尔)联合使用可能有助于恢复cAMP含量和腺苷酸环化酶活性。

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