Gähwiler B H, Herrling P L
Regul Pept. 1981 Feb;1(5):317-26. doi: 10.1016/0167-0115(81)90055-0.
Bath application of 10(-8) M FK 33-824 (an enkephalin analogue) and 10(-7) M beta-endorphin reversibly induced stimulus-evoked bursting activity with depolarization shifts in cultured hippocampal pyramidal cells. Statistical analysis of the data revealed that in the majority of cells, inhibitory postsynaptic potentials were markedly decreased and excitatory postsynaptic potentials increased prior to the development of bursting activity, although some inhibition persisted in cells exposed to opioid peptides. In a minority of cells, no alteration in synaptic potentials were observed to precede the stimulus-evoked bursts induced by the opioid peptides.
在培养的海马锥体细胞中，浴用10⁻⁸ M FK 33 - 824（一种脑啡肽类似物）和10⁻⁷ M β-内啡肽可通过去极化偏移可逆地诱导刺激诱发的爆发性活动。数据的统计分析显示，在大多数细胞中，在爆发性活动出现之前，抑制性突触后电位显著降低，兴奋性突触后电位增加，尽管在暴露于阿片肽的细胞中仍有一些抑制作用存在。在少数细胞中，在阿片肽诱导的刺激诱发爆发之前，未观察到突触电位有改变。
