Haas H L, Gähwiler B H
Neurosci Lett. 1980 Aug;19(1):89-92. doi: 10.1016/0304-3940(80)90261-x.
Although bath application of 10(-6) g/ml tetrodotoxin abolished the fast action potentials of pyramidal cells in hippocampal slices of rats, action potentials of lower amplitude and longer duration could still be evoked by intracellular current injection. FK 33-824 (an enkephalin analogue) had no effect on the threshold or shape of these presumed calcium-spikes. These data suggest that enkephalins, which induce bursting discharges in pyramidal cells, do not exert this action by a direct effect on inward calcium movement through the pyramidal cell membrane.
虽然在大鼠海马切片中，浴用10(-6)克/毫升的河豚毒素可消除锥体细胞的快速动作电位，但通过细胞内电流注入仍可诱发幅度较低、持续时间较长的动作电位。FK 33-824（一种脑啡肽类似物）对这些假定的钙峰的阈值或形状没有影响。这些数据表明，在锥体细胞中诱发爆发性放电的脑啡肽，并非通过直接影响钙经锥体细胞膜的内向移动来发挥这种作用。
