儿童非典型淋巴细胞增多症。

Atypical lymphocytosis in children.

作者信息

Fleisher G, Paradise J

出版信息

Ann Emerg Med. 1981 Aug;10(8):424-6. doi: 10.1016/s0196-0644(81)80310-1.

Abstract

A complete blood count performed during the evaluation of a febrile or traumatized child may show the presence of atypical lymphocytosis. Although atypical lymphocytes occur in several conditions, they are most closely associated with infectious mononucleosis (IM). We initiated a study to determine if the presence in children of atypical lymphocytosis without the triad of splenomegaly, pharyngitis, and adenopathy is a manifestation of IM. Heterophil antibody (HA) and Epstein-Barr virus (EBV) titers were performed on 45 children with greater than or equal to 5% atypical lymphocytes. None had a significant HA titer. Thirty-three were seronegative for EBV, and 11 had titers indicative of past infection. One child had an antibody pattern suggesting a recent EBV infection; none had a titer consistent with acute IM. We conclude that isolated atypical lymphocytes does not point to infectious mononucleosis.

摘要

在对发热或受创伤儿童进行评估时进行的全血细胞计数可能显示存在非典型淋巴细胞。虽然非典型淋巴细胞在多种情况下都会出现，但它们与传染性单核细胞增多症（IM）关系最为密切。我们开展了一项研究，以确定在儿童中出现的非典型淋巴细胞增多而无脾肿大、咽炎和腺病三联征是否为IM的一种表现。对45名非典型淋巴细胞≥5%的儿童进行了嗜异性抗体（HA）和爱泼斯坦-巴尔病毒（EBV）滴度检测。无一例HA滴度显著升高。33例EBV血清学阴性，11例滴度表明既往感染。1名儿童的抗体模式提示近期EBV感染；无一例滴度与急性IM相符。我们得出结论，孤立的非典型淋巴细胞增多并不提示传染性单核细胞增多症。