创伤会影响受伤及未受伤的远端口腔黏膜部位的环磷酸腺苷（cAMP）和DNA水平。

Trauma affects cyclic AMP and DNA levels at injured and non-injured distal oral mucosal sites.

作者信息

Fine A S, Egnor R W, Stahl S S

出版信息

Arch Dermatol Res. 1981;270(1):7-15. doi: 10.1007/BF00417144.

Abstract

Experiments in rats were conducted to test the hypothesis that gingival trauma affects cyclic AMP and DNA levels at the gingival wound, and non-injured distal (gingival, palatal) sites. Cyclic AMP and DNA levels rose and fell in a cyclic fashion during the time (0.5-24 h) periods analyzed. Significant increases in cAMP levels occurred at 8 and 20 h and at 8 and 16 h, respectively, at the wound and non-injured palatal site, peripheral to the wound. Similar increases (not significant) in cAMP levels were also noted at the non-injured gingival contralateral site at the same time intervals. DNA distributions were found to be significantly greater 10 and 16 h after injury at the gingival wound, and distal non-injured gingival and palatal sites.

摘要

在大鼠身上进行了实验，以检验以下假设：牙龈创伤会影响牙龈伤口处以及未受伤的远侧（牙龈、腭部）部位的环磷酸腺苷（cAMP）和DNA水平。在分析的时间段（0.5 - 24小时）内，cAMP和DNA水平呈周期性上升和下降。在伤口处以及伤口周围未受伤的腭部部位，cAMP水平分别在8小时和20小时以及8小时和16小时出现显著升高。在相同时间间隔，未受伤的对侧牙龈部位的cAMP水平也有类似升高（不显著）。发现在牙龈伤口以及远侧未受伤的牙龈和腭部部位，受伤后10小时和16小时的DNA分布显著增加。