Kasumov K M, Mekhtiev N K, Karakozov S D
Biochim Biophys Acta. 1981 Jun 22;644(2):369-72. doi: 10.1016/0005-2736(81)90395-3.
The aromatic polyene antibiotic levorin A2 forms ion channels permeable to monovalent cations, in lipid membranes containing cholesterol or ergosterol. Channel conductivity is in the range 0.3-0.5 pS. The channel has two main states: conducting (open) and nonconducting (closed). The potential-dependent formation of levorin A2 channels is observed in lipid membranes. The system responsible for the ion-channel selectively is localized on the hydrophilic side of the lactone ring of the polyene molecule.
芳香族多烯抗生素左菌素A2在含有胆固醇或麦角固醇的脂质膜中形成对单价阳离子通透的离子通道。通道电导率在0.3 - 0.5皮西门子范围内。该通道有两种主要状态：导通（开放）和不导通（关闭）。在脂质膜中观察到左菌素A2通道的电位依赖性形成。负责离子通道选择性的系统定位于多烯分子内酯环的亲水性一侧。
