Ramírez Mayans J, Salas Alvarado M, Coutiño B
Bol Med Hosp Infant Mex. 1978 Mar-Apr;35(2):343-54.
Muscular disturbances in hypothyroid children are: generalized muscular weakness of proximal predominance, muscular hypotonicity, pseudohypertrophy (of gastrocnemius muscles chiefly), slow relaxation stage of osteotendinous reflexes, rise of muscular enzymes (CPK andaldolase), unspecific electromyographic changes and histopathologic disturbances comprised by persistent decrease of fibers type II. All these changes are reversible with thyroglobulin therapy; therefore they exert no influence on the prognosis of hypothyroid patients.
以近端为主的全身性肌肉无力、肌肉张力减退、假性肥大(主要是腓肠肌)、骨腱反射的松弛期延长、肌肉酶(肌酸磷酸激酶和醛缩酶)升高、非特异性肌电图改变以及由II型纤维持续减少构成的组织病理学紊乱。所有这些改变在接受甲状腺球蛋白治疗后均可逆转;因此,它们对甲状腺功能减退患者的预后没有影响。