毒蕈碱-多巴胺能对视网膜环磷酸腺苷形成的协同作用。
Muscarinic-dopaminergic synergism on retinal cyclic AMP formation.
作者信息
Brown J H, Rietow M
出版信息
Brain Res. 1981 Jun 29;215(1-2):388-92. doi: 10.1016/0006-8993(81)90522-9.
PMID:6266579
Abstract
The cholinergic agonist, carbachol, produces a small increase in cyclic AMP concentration in the isolated rat retina, and markedly potentiates dopamine-stimulated cyclic AMP formation. This effect of carbachol is mediated through a muscarinic receptor, is calcium-independent, and is not due to inhibition of phosphodiesterase activity. Activation of muscarinic receptors may potentiate dopaminergic responses in the retina by enhancing coupling of the dopamine receptor to adenylate cyclase.
摘要
胆碱能激动剂卡巴胆碱可使离体大鼠视网膜中的环磷酸腺苷（cAMP）浓度略有升高，并显著增强多巴胺刺激的cAMP生成。卡巴胆碱的这种作用是通过毒蕈碱受体介导的，与钙无关，且不是由于磷酸二酯酶活性受到抑制。毒蕈碱受体的激活可能通过增强多巴胺受体与腺苷酸环化酶的偶联来增强视网膜中的多巴胺能反应。
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