Panula P, Wu J Y, Emson P
Brain Res. 1981 Aug 24;219(1):202-7. doi: 10.1016/0006-8993(81)90283-3.
The subcellular distribution of glutamate decarboxylase (GAD) was revealed by electron microscopic immunocytochemistry in primary cultures of the rat neostriatum. Immunoreactivity was restricted to a small nerve cell type with rich amounts of free ribosomes and an indented nucleus. Glial cells were non-reactive. The results indicate that GABA-synthesizing neurons are viable in culture conditions and suggest that neostriatal GABA-neurons are small cells with simple ultrastructure since larger cells did not possess immunoreactivity.
