Kubota Y, Inagaki S, Kito S, Wu J Y
Brain Res. 1987 Mar 17;406(1-2):147-56. doi: 10.1016/0006-8993(87)90779-7.
We examined with an electron microscopic 'mirror technique' whether glutamic acid decarboxylase-immunoreactive (GAD-IR) neurons are in direct synaptic contact with tyrosine hydroxylase-immunoreactive (TH-IR) axons in the rat neostriatum. Three types of GAD-IR neurons were identified in the nucleus caudatus putamen based upon their size and ultrastructural characteristics. These were medium spiny, medium aspiny and large cells. All types of GAD-IR neurons made synaptic contact with TH-IR axonal boutons at least on perikarya and proximal dendrites. This provides ultrastructural evidence for catecholaminergic, presumably, nigrostriatal dopaminergic inputs to both long- and short-axon neurons most probably containing GABA.
我们运用电子显微镜“镜像技术”研究了大鼠新纹状体内谷氨酸脱羧酶免疫反应性（GAD-IR）神经元是否与酪氨酸羟化酶免疫反应性（TH-IR）轴突存在直接的突触联系。根据尾壳核中GAD-IR神经元的大小和超微结构特征，鉴定出三种类型的神经元。它们分别是中等棘状神经元、中等无棘神经元和大细胞。所有类型的GAD-IR神经元至少在胞体和近端树突上与TH-IR轴突终扣形成了突触联系。这为儿茶酚胺能（推测为黑质纹状体多巴胺能）向极有可能含有γ-氨基丁酸的长轴突和短轴突神经元输入提供了超微结构证据。
