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各种瓜尔豆胶之间的粘度差异。

Viscosity differences between various guar gums.

作者信息

O'Connor N, Tredger J, Morgan L

出版信息

Diabetologia. 1981 Jun;20(6):612-5. doi: 10.1007/BF00257429.

Abstract

Guar gum from four industrial sources was investigated. The viscosity of two preparations of hydrated guar gum in the form of powdered flour and one granulate flour was measured at 22 degrees and 32 degrees C and pH 1.0 and pH 4.0. Viscosity measurements on wax-coated guar granules proved impossible but visual assessment indicated an extremely low viscosity in all conditions. These findings were compared with the ability of the equivalent of 5 g guar gum of the various preparations to modify the absorption of a 50 g liquid glucose load. The mean post-prandial blood glucose curve was not significantly different from the control situation after the incorporation of each preparation. Despite the granulate flour attaining a considerably lower viscosity than the powdered flour they were equally effective in significantly reducing the mean post-prandial insulin curve (area under the curve (0-180 min) reduced by 46 and 50% respectively). The wax-coated granules which achieved minimal viscosity caused significantly less reduction of post-prandial insulin levels (area under the curve reduced by 37%). The viscosity of guar gum upon hydration is of importance in assessing the efficacy of a preparation in clinical use.

摘要

对来自四个工业来源的瓜尔胶进行了研究。在22摄氏度和32摄氏度、pH值为1.0和pH值为4.0的条件下,测量了两种呈面粉状的水合瓜尔胶制剂以及一种颗粒状面粉的粘度。对涂蜡瓜尔胶颗粒进行粘度测量被证明是不可能的,但目视评估表明在所有条件下其粘度极低。将这些结果与相当于5克各种制剂瓜尔胶改变50克液体葡萄糖负荷吸收的能力进行了比较。在加入每种制剂后,餐后平均血糖曲线与对照情况相比无显著差异。尽管颗粒状面粉的粘度远低于粉末状面粉,但它们在显著降低餐后平均胰岛素曲线方面同样有效(曲线下面积(0 - 180分钟)分别降低了46%和50%)。粘度最小的涂蜡颗粒导致餐后胰岛素水平降低显著较少(曲线下面积降低了37%)。瓜尔胶水合后的粘度对于评估制剂在临床使用中的疗效很重要。

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