Holt S, Heading R C, Carter D C, Prescott L F, Tothill P
Lancet. 1979 Mar 24;1(8117):636-9. doi: 10.1016/s0140-6736(79)91079-1.
To determine the part played by altered gastric emptying in the modification of glucose absorption by gel fibres, glucose tolerance tests were done in seven healthy volunteers with and without the addition of pectin to the ingested glucose solution and after pharmacological inhibition of gastric emptying with propantheline. Compared with the controls, pectin significantly reduced blood-glucose. Propantheline had a similar but more pronounced effect. Pectin and guar gum did not substantially alter glucose tolerance in a patient who had had total gastrectomy. In a further investigation, gastric emptying and paracetamol absorption were studied simultaneously in fourteen subjects. In eight of these the study was repeated after addition of guar gum and pectin to the ingested paracetamol. Both gastric emptying and paracetamol absorption were slower after gel fibre but the total absorption of the drug, reflected in urinary recovery, was not significantly reduced. The results suggest that the effects of guar gum and pectin on glucose tolerance and paracetamol absorption could be due simply to alteration in the rate of gastric emptying.
为了确定胃排空改变在凝胶纤维对葡萄糖吸收的影响中所起的作用，对7名健康志愿者进行了葡萄糖耐量试验，分别在摄入的葡萄糖溶液中添加和不添加果胶的情况下进行，以及在使用丙胺太林进行胃排空的药理抑制后进行。与对照组相比，果胶显著降低了血糖。丙胺太林有类似但更明显的效果。果胶和瓜尔胶对一名全胃切除患者的葡萄糖耐量没有实质性改变。在进一步的研究中，对14名受试者同时进行了胃排空和对乙酰氨基酚吸收的研究。其中8名受试者在摄入的对乙酰氨基酚中添加瓜尔胶和果胶后重复了该研究。凝胶纤维摄入后胃排空和对乙酰氨基酚吸收均减慢，但反映在尿液回收率中的药物总吸收并未显著降低。结果表明，瓜尔胶和果胶对葡萄糖耐量和对乙酰氨基酚吸收的影响可能仅仅是由于胃排空速率的改变。
