Ben-Uriah Y, Yehuda S, Carasso R L
Int J Neurosci. 1981;14(1-2):41-6. doi: 10.3109/00207458108985814.
In recent studies carried out during the last decade, it has been found that beta-blocker agents have many central effects. These findings raise the question how beta-blocker agents act when they influence central effects. In spite of intensive research efforts on this subject, no answer has been offered so far. Several studies indicate that the effect of beta-blocker agents on the dopaminergic receptors in the brain is very similar to their effect on beta-adrenergic receptors. In a set of experiments we checked the effect of two beta-blocker agents: oxprenolol and dl-propranolol, and the effect of d-propranolol on hypothermia induced by d-amphetamine and apomorphine at an ambient temperature of 4 degrees C. It was found that the two beta-blockers and the d-propranolol significantly potentiated the effect of hypothermia induced by d-amphetamine and apomorphine, an effect which is mediated by the central dopaminergic system. However, the activity of the beta-blockers was agonistic. Furthermore, the influence of d-propranolol on hypothermia shows that this dopaminergic agonistic activity of the beta-blockers is not related to peripheral or central beta-receptor blockage.
在过去十年间开展的近期研究中发现，β受体阻滞剂具有多种中枢效应。这些发现引发了一个问题，即β受体阻滞剂在影响中枢效应时是如何发挥作用的。尽管针对该主题进行了大量深入研究，但目前尚未给出答案。多项研究表明，β受体阻滞剂对大脑中多巴胺能受体的作用与其对β肾上腺素能受体的作用非常相似。在一组实验中，我们检测了两种β受体阻滞剂：氧烯洛尔和消旋普萘洛尔，以及右旋普萘洛尔对在4摄氏度环境温度下由右旋苯丙胺和阿扑吗啡诱导的体温过低的影响。结果发现，这两种β受体阻滞剂以及右旋普萘洛尔均显著增强了由右旋苯丙胺和阿扑吗啡诱导的体温过低效应，该效应由中枢多巴胺能系统介导。然而，β受体阻滞剂的活性具有激动作用。此外，右旋普萘洛尔对体温过低的影响表明，β受体阻滞剂的这种多巴胺能激动活性与外周或中枢β受体阻滞无关。
