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1
Calcium-regulatory mechanisms. Functional classification using skinned fibers.钙调节机制。使用剥除肌膜纤维的功能分类。
J Gen Physiol. 1981 Feb;77(2):177-90. doi: 10.1085/jgp.77.2.177.
2
Regulation of Ca2+-activated tension in limulus striated muscle.鲎横纹肌中钙激活张力的调节。
Pflugers Arch. 1981 Dec;392(2):121-4. doi: 10.1007/BF00581259.
3
Evidence that myosin light chain phosphorylation regulates contraction in the body wall muscles of the sea cucumber.肌球蛋白轻链磷酸化调节海参体壁肌肉收缩的证据。
J Cell Physiol. 1982 Sep;112(3):307-15. doi: 10.1002/jcp.1041120302.
4
Vascular smooth muscle. Calmodulin and cyclic AMP-dependent protein kinase after calcium sensitivity in porcine carotid skinned fibers.血管平滑肌。猪颈动脉去表皮纤维中钙敏感性后的钙调蛋白和环磷酸腺苷依赖性蛋白激酶。
Circ Res. 1982 Mar;50(3):394-9. doi: 10.1161/01.res.50.3.394.
5
Trifluoperazine inhibition of contraction in permeabilized skeletal, cardiac and smooth muscles.三氟拉嗪对透化骨骼肌、心肌和平滑肌收缩的抑制作用。
Biochem Biophys Res Commun. 1990 Feb 14;166(3):1421-8. doi: 10.1016/0006-291x(90)91025-n.
6
Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase.环磷酸腺苷依赖性蛋白激酶对平滑肌张力的抑制作用。
Nature. 1981 Jul 16;292(5820):253-5. doi: 10.1038/292253a0.
7
Effect of calmodulin, Ca2+, and cAMP protein kinase on skinned tracheal smooth muscle.钙调蛋白、钙离子和环磷酸腺苷蛋白激酶对去表皮气管平滑肌的作用。
Am J Physiol. 1984 Mar;246(3 Pt 1):C308-14. doi: 10.1152/ajpcell.1984.246.3.C308.
8
Phosphorylation-dependent activated tension in skinned gizzard muscle fibers in the absence of Ca2+.在无Ca2+情况下，去皮砂囊肌纤维中磷酸化依赖性激活张力。
J Biol Chem. 1982 Jun 10;257(11):5987-90.
9
Inhibition of Ca2+-activated tension and myosin light chain phosphorylation in skinned smooth muscle strips by the phenothiazines.吩噻嗪类药物对去表皮平滑肌条中钙激活张力和肌球蛋白轻链磷酸化的抑制作用。
Pflugers Arch. 1980 Sep;387(2):115-20. doi: 10.1007/BF00584261.
10
Contractile responses to MgATP and pH in a thick filament regulated muscle: studies with skinned scallop fibers.粗丝调节型肌肉对MgATP和pH的收缩反应：用去皮扇贝纤维进行的研究
Adv Exp Med Biol. 1984;170:569-72. doi: 10.1007/978-1-4684-4703-3_51.

引用本文的文献

1
Invertebrate muscles: thin and thick filament structure; molecular basis of contraction and its regulation, catch and asynchronous muscle.无脊椎动物肌肉：细肌丝和粗肌丝结构；收缩及其调节的分子基础、牵张肌和异步肌。
Prog Neurobiol. 2008 Oct;86(2):72-127. doi: 10.1016/j.pneurobio.2008.06.004. Epub 2008 Jun 20.
2
Regulation of Ca2+-activated tension in limulus striated muscle.鲎横纹肌中钙激活张力的调节。
Pflugers Arch. 1981 Dec;392(2):121-4. doi: 10.1007/BF00581259.
3
Exogenous calmodulin increases Ca2+ sensitivity of isometric tension activation and myosin phosphorylation in skinned smooth muscle.外源性钙调蛋白可增加去表皮平滑肌等长张力激活和肌球蛋白磷酸化的钙离子敏感性。
Pflugers Arch. 1981 Dec;392(2):115-20. doi: 10.1007/BF00581258.
4
Effects of chlorpromazine on the electrical and mechanical properties of intact and skinned muscle cells of guinea-pig mesenteric artery.氯丙嗪对豚鼠肠系膜动脉完整和去膜肌细胞电特性和机械特性的影响。
Br J Pharmacol. 1982 Mar;75(3):513-23. doi: 10.1111/j.1476-5381.1982.tb09168.x.
5
The inhibitory effects of N2-dansyl-L-arginine-4-t-butylpiperidine amide (TI233) on contraction of vascular and intestinal smooth muscle.N2-丹磺酰-L-精氨酸-4-叔丁基哌啶酰胺（TI233）对血管和平滑肌收缩的抑制作用。
Br J Pharmacol. 1983 Nov;80(3):519-25. doi: 10.1111/j.1476-5381.1983.tb10724.x.
6
Receptor capping in mouse T-lymphoma cells: a Ca2+ and calmodulin-stimulated ATP-dependent process.小鼠T淋巴瘤细胞中的受体封帽：一种Ca2+和钙调蛋白刺激的ATP依赖性过程。
J Membr Biol. 1983;75(1):65-72. doi: 10.1007/BF01870800.
7
Regulation of receptor capping in mouse lymphoma T cells by Ca2+-activated myosin light chain kinase.钙离子激活的肌球蛋白轻链激酶对小鼠淋巴瘤T细胞中受体盖帽的调控
Proc Natl Acad Sci U S A. 1984 Jan;81(1):165-9. doi: 10.1073/pnas.81.1.165.
8
Effects of EDTA treatment upon the protein subunit composition and mechanical properties of mammalian single skeletal muscle fibers.乙二胺四乙酸（EDTA）处理对哺乳动物单根骨骼肌纤维蛋白质亚基组成和力学性能的影响。
J Cell Biol. 1983 Apr;96(4):970-8. doi: 10.1083/jcb.96.4.970.
9
Mechanisms of relaxation induced by activation of beta-adrenoceptors in smooth muscle cells of the guinea-pig mesenteric artery.豚鼠肠系膜动脉平滑肌细胞中β-肾上腺素能受体激活诱导的舒张机制。
J Physiol. 1982 May;326:475-93. doi: 10.1113/jphysiol.1982.sp014207.
10
Effects of ritodrine, a beta 2-adrenoceptor agonist, on smooth muscle cells of the myometrium of pregnant rats.β2肾上腺素能受体激动剂利托君对妊娠大鼠子宫肌层平滑肌细胞的影响。
Br J Pharmacol. 1982 Jul;76(3):463-71. doi: 10.1111/j.1476-5381.1982.tb09241.x.

本文引用的文献

1
Calcium-activated tension: the role of myosin light chain phosphorylation.钙激活张力：肌球蛋白轻链磷酸化的作用
Fed Proc. 1980 Apr;39(5):1558-63.
2
Myosin light chain phosphorylation during the contraction cycle of frog muscle.青蛙肌肉收缩周期中的肌球蛋白轻链磷酸化。
Fed Proc. 1980 Apr;39(5):1547-51.
3
Phosphorylation by cyclic adenosine 3':5'-monophosphate-dependent protein kinase regulates myosin light chain kinase.环磷腺苷依赖性蛋白激酶的磷酸化作用可调节肌球蛋白轻链激酶。
Fed Proc. 1980 Apr;39(5):1569-73.
4
Force measurements in skinned muscle fibres.对去表皮肌纤维的力测量。
J Physiol. 1969 Feb;200(3):807-19. doi: 10.1113/jphysiol.1969.sp008723.
5
Troponin. I. Preparation and physiological function.肌钙蛋白I. 制备及生理功能
J Biochem. 1968 Oct;64(4):465-77. doi: 10.1093/oxfordjournals.jbchem.a128918.
6
The interaction of the calcium-binding protein (troponin C) with bivalent cations and the inhibitory protein (troponin I).钙结合蛋白（肌钙蛋白C）与二价阳离子及抑制蛋白（肌钙蛋白I）之间的相互作用。
Biochem J. 1974 Feb;137(2):145-54. doi: 10.1042/bj1370145.
7
Molecular control mechanisms in muscle contraction.肌肉收缩中的分子控制机制。
Physiol Rev. 1973 Jul;53(3):612-73. doi: 10.1152/physrev.1973.53.3.612.
8
Adenosine 5'-O(3-thiotriphosphate) in the control of phosphorylase activity.5'-O(3-硫代三磷酸)腺苷对磷酸化酶活性的调控
Biochem Biophys Res Commun. 1974 Jun 18;58(4):960-7. doi: 10.1016/s0006-291x(74)80237-8.
9
Identification of the transitory complex myosin-ATP by the use of , -methylene-ATP.通过使用α,β-亚甲基三磷酸腺苷鉴定瞬时复合物肌球蛋白-三磷酸腺苷。
Nat New Biol. 1973 Feb 21;241(112):226-9. doi: 10.1038/newbio241226a0.
10
Purification and properties of the components from troponin.肌钙蛋白各组分的纯化及特性
J Biol Chem. 1973 Mar 25;248(6):2125-33.

钙调节机制。使用剥除肌膜纤维的功能分类。

Calcium-regulatory mechanisms. Functional classification using skinned fibers.

作者信息

Kerrick W G, Hoar P E, Cassidy P S, Bolles L, Malencik D A

出版信息

J Gen Physiol. 1981 Feb;77(2):177-90. doi: 10.1085/jgp.77.2.177.

DOI:10.1085/jgp.77.2.177
PMID:6267161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2215427/
Abstract

The primary purpose of this study was to determine whether various agents (adenosine 3-thiotriphosphate [ATP gamma S], trifluoperazine [TFP], troponin I, the catalytic subunit of the cyclic adenosine 3',5'-monophosphate dependent protein kinase [C-subunit], and calmodulin [CaM]) could be used to classify skinned fiber types, and then to determine whether the proposed mechanisms for Ca2+ regulation were consistent with the results. Agents (ATP gamma S, TFP, C-subunit, CaM) expected to alter a light chain kinase-phosphatase system strongly affect the Ca2+-activated tension in skinned gizzard smooth muscle fibers, whereas these agents have no effect on skinned mammalian striated and scallop adductor fibers. Troponin I, which is known to bind strongly to troponin C and CaM, inhibits Ca2+ activation of skinned mammalian striated and gizzard fibers but not scallop adductor muscle. The results in different types of skinned fibers are consistent with proposed mechanisms for Ca2+ regulation.

摘要

本研究的主要目的是确定各种试剂（腺苷3 - 硫代三磷酸[ATPγS]、三氟拉嗪[TFP]、肌钙蛋白I、环磷酸腺苷依赖性蛋白激酶催化亚基[C亚基]和钙调蛋白[CaM]）是否可用于对去表皮纤维类型进行分类，然后确定所提出的Ca2 +调节机制是否与结果一致。预期会改变轻链激酶 - 磷酸酶系统的试剂（ATPγS、TFP、C亚基、CaM）强烈影响去表皮的砂囊平滑肌纤维中Ca2 +激活的张力，而这些试剂对去表皮的哺乳动物横纹肌纤维和扇贝闭壳肌纤维没有影响。已知与肌钙蛋白C和CaM紧密结合的肌钙蛋白I抑制去表皮的哺乳动物横纹肌纤维和砂囊纤维的Ca2 +激活，但不抑制扇贝闭壳肌。不同类型去表皮纤维的结果与所提出的Ca2 +调节机制一致。