蕈样肉芽肿中的淋巴细胞毒性。

Lymphocytotoxicity in mycosis fungoides.

作者信息

Price N M, Mirkovich A M

出版信息

Br J Dermatol. 1978 Jan;98(1):97-102. doi: 10.1111/j.1365-2133.1978.tb07338.x.

DOI:10.1111/j.1365-2133.1978.tb07338.x

Abstract

The phenomenon of lymphocytotoxicity was demonstrated in 29 patients with mycosis fungoides, using a newly described epithelial cell culture system and an isotope marker, 125Iododeoxyuridine (125IUdR). Lymphocytotoxicity was demonstrated in patients in the generalized plaque and the erythroderma phases of the disease (P is less than or equal to 0.05). No significant lymphocytotoxicity was demonstrable in patients who were in the limited plaque (early) phase of the disease. It is hypothesized that this demonstration of lymphocytotoxicity in patients may be a manifestation of a delayed hypersensitivity response to an as yet unidentified antigen in the epidermis.

摘要

利用一种新描述的上皮细胞培养系统和一种同位素标记物125碘脱氧尿苷（125IUdR），在29例蕈样肉芽肿患者中证实了淋巴细胞毒性现象。在疾病的泛发性斑块期和红皮病期患者中证实了淋巴细胞毒性（P小于或等于0.05）。在疾病的局限性斑块（早期）期患者中未证实有明显的淋巴细胞毒性。据推测，患者中这种淋巴细胞毒性的证实可能是对表皮中一种尚未确定的抗原的迟发型超敏反应的表现。