通过显示酸性非特异性酯酶的颗粒活性对皮肤T细胞淋巴瘤中的T淋巴细胞进行原位鉴定和计数。

In situ identification and enumeration of T lymphocytes in cutaneous T-cell lymphomas by demonstration of granular activity of acid non-specific esterase.

作者信息

Sterry W, Steigleder G K, Pullmann H

出版信息

Br J Dermatol. 1980 Jul;103(1):67-72. doi: 10.1111/j.1365-2133.1980.tb15839.x.

DOI:10.1111/j.1365-2133.1980.tb15839.x

Abstract

Activity of acid non-specific esterase (ANAE) in infiltrating lymphocytes in nine patients with mycosis fungoides and four patients with parapsoriasis en plaques was examined in frozen tissue sections. Within the dermal infiltrate 81.7 +/- 6.1% of all lymphocytes contain this enzyme in mycosis fungoides, 74.7 +/- 3.3% in parapsoriasis en plaques. These results correlate well with the percentage of T lymphocytes determined by immunological techniques. Mycosis fungoides may be regarded as an ANAE-positive cutaneous T-cell lymphoma. Because of its simplicity this technique may be of value in further investigations of mycosis fungoides.

摘要

在冷冻组织切片中检查了9例蕈样肉芽肿患者和4例斑块状副银屑病患者浸润淋巴细胞中的酸性非特异性酯酶（ANAE）活性。在蕈样肉芽肿患者的真皮浸润中，所有淋巴细胞中有81.7±6.1%含有这种酶，在斑块状副银屑病患者中为74.7±3.3%。这些结果与通过免疫技术测定的T淋巴细胞百分比密切相关。蕈样肉芽肿可被视为一种ANAE阳性的皮肤T细胞淋巴瘤。由于该技术操作简单，可能对蕈样肉芽肿的进一步研究有价值。