Gutjahr P
Klin Padiatr. 1981 May;193(3):213-24. doi: 10.1055/s-2008-1034462.
Treatment results in children with Wilms' tumors have remarkably improved during the past ten years. This is the most important aspect in modern Wilms' tumor research. Further, new etiologic factors have been identified. Modern diagnostic procedures (with special reference to an eventual preoperative treatment), aspects of "staging" and "grading", the changed prognosis and handling of bilateral tumors, the identification of infantile congeners of Wilms' tumors and the often realized optimal interdisciplinary cooperative treatment have allowed to design the former mostly fatal tumors as outstanding in clinical oncology. This paper summarizes the recent data available from the literature; several problems remain unresolved. Among open questions are a better preoperative diagnosis, standardization of treatment of stage-IV-patients, determination of the role of adriamycin in chemotherapy, and the comprehensive and thorough study of late effects.
在过去十年中，肾母细胞瘤患儿的治疗效果有了显著改善。这是现代肾母细胞瘤研究中最重要的方面。此外，已确定了新的病因。现代诊断程序（特别是关于可能的术前治疗）、“分期”和“分级”方面、双侧肿瘤预后和处理的变化、肾母细胞瘤婴儿型同源物的鉴定以及经常实现的最佳多学科合作治疗，使得以前大多致命的肿瘤在临床肿瘤学中表现出色。本文总结了文献中的最新数据；仍有几个问题未得到解决。未解决的问题包括更好的术前诊断、IV期患者治疗的标准化、阿霉素在化疗中的作用的确定以及对远期效应的全面深入研究。
