Lindgren J E, Ohlsson A, Agurell S, Hollister L, Gillespie H
Psychopharmacology (Berl). 1981;74(3):208-12. doi: 10.1007/BF00427095.
delta 9-Tetrahydrocannabinol (delta 9-THC) was administered in a crossover design by smoking and IV injection to groups of heavy and light users of marihuana. Plasma concentrations of delta 9-THC were similar for the groups after IV injection of 5.0 mg delta 9-THC, but the AUC0-240 min showed a trend towards lower values for the heavy user group. To achieve a maximum desired "high", both groups smoked similar amounts (about 13 mg) of delta 9-THC. Heavy users tended to have higher plasma levels than light users. The systemic availability of smoked delta 9-THC was significantly higher for the heavy users (heavy users 23 +/- 16% vs 10 +/- 7% for light users). These results also indicate that heavy cannabis users smoke more efficiently than casual smokers. Both light and heavy users showed more clinical effect following IV administration than after smoking. The response of the heavy users, both with respect to effect on heart and "high", was quite comparable to that of light users. The present study does not suggest that tolerance readily develops in heavy users.
采用交叉设计，通过吸烟和静脉注射的方式，将δ9 - 四氢大麻酚（δ9 - THC）给予重度和轻度大麻使用者群体。静脉注射5.0毫克δ9 - THC后，两组的δ9 - THC血浆浓度相似，但重度使用者组的AUC0 - 240分钟呈现出较低值的趋势。为达到最大期望的“快感”，两组吸入了相似量（约13毫克）的δ9 - THC。重度使用者的血浆水平往往高于轻度使用者。重度使用者吸入的δ9 - THC的全身可用性显著更高（重度使用者为23±16%，轻度使用者为10±7%）。这些结果还表明，重度大麻使用者比偶尔吸烟者吸烟效率更高。轻度和重度使用者静脉给药后的临床效应均比吸烟后更明显。重度使用者在对心脏的影响和“快感”方面的反应与轻度使用者相当。本研究并未表明重度使用者容易产生耐受性。
