Ohlsson A, Lindgren J E, Wahlén A, Agurell S, Hollister L E, Gillespie H K
Biomed Mass Spectrom. 1982 Jan;9(1):6-10. doi: 10.1002/bms.1200090103.
Deuterium labelled delta 1-tetrahydrocannabinol was administered intravenously (5.0 mg) and by smoking (10.0 mg) to five heavy and four light marihuana users. All subjects smoked an estimated amount of 8.6-9.9 mg delta 1-tetrahydrocannabinol. The plasma levels of delta 1-tetrahydrocannabinol were followed for 48 hours and in two subjects fof 72 hours after administration. The systemic availability after inhalation calculated from the area under curve values was in the range of 27 +/- 10% for the heavy users and 14 +/- 1% for the light users. There was little difference between the groups with regard to the amount of smoked delta 1-tetrahydrocannabinol or plasma levels and area under curve values obtained after i.v. administration. Thus, it seems likely that the statistically significant difference in systemic availability of smoked delta 1-tetrahydrocannabinol was due to a more efficient smoking by the heavy users. It is also indicated that heavy users prefer slightly higher delta 1-tetrahydrocannabinol plasma levels than light users. Based on the area under curve values after i.v. administration, a plasma clearance of 760-1190 ml min-1 was calculated. The elimination half-life of delta 1-tetrahydrocannabinol is more than 20 hours. The present results do not suggest that tolerance or sensitivity to delta 1-tetrahydrocannabinol in heavy users is readily achieved.
将氘标记的δ1-四氢大麻酚以静脉注射（5.0毫克）和吸烟（10.0毫克）的方式给予5名重度大麻使用者和4名轻度大麻使用者。所有受试者吸食的δ1-四氢大麻酚估计量为8.6 - 9.9毫克。给药后对δ1-四氢大麻酚的血浆水平进行了48小时的跟踪，两名受试者跟踪了72小时。根据曲线下面积值计算，重度使用者吸入后的全身可用性范围为27±10%，轻度使用者为14±1%。在吸食的δ1-四氢大麻酚量、血浆水平以及静脉给药后获得的曲线下面积值方面，两组之间几乎没有差异。因此，吸食的δ1-四氢大麻酚在全身可用性上的统计学显著差异似乎是由于重度使用者吸烟效率更高。研究还表明，重度使用者比轻度使用者更喜欢略高的δ1-四氢大麻酚血浆水平。根据静脉给药后的曲线下面积值，计算出血浆清除率为760 - 1190毫升/分钟。δ1-四氢大麻酚的消除半衰期超过20小时。目前的结果并不表明重度使用者对δ1-四氢大麻酚容易产生耐受性或敏感性。
