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Inhibition of the BamHI cleavage and unwinding of pBR322 deoxyribonucleic acid by the antitumor drug cis-dichlorodiammineplatinum(II).

作者信息

Ushay H M, Tullius T D, Lippard S J

出版信息

Biochemistry. 1981 Jun 23;20(13):3744-8. doi: 10.1021/bi00516a012.

DOI:10.1021/bi00516a012
PMID:6268142
Abstract
摘要

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Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro.针对顺二氯二氨铂(II)修饰的DNA产生的抗体对体内和体外形成的顺二氯二氨铂(II)-DNA加合物具有特异性。
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