Lijinsky W, Reuber M D
Cancer Lett. 1981 Mar;12(1-2):99-103. doi: 10.1016/0304-3835(81)90044-6.
Three homologous cyclic nitrosamines, nitrosopyrrolidine, nitrosopiperidine and nitrosohexamethyleneimine, were administered to groups of 20 female F344 rats in drinking water, as 0.9 mM solutions. Treatment with the latter 2 compounds lasted 28 weeks, at which time several animals had died with esophageal tumors. All of the animals in these 2 groups were dead by the 36th week of the experiment. Most of the animals given nitrosohexamethyleneimine also had angiosarcomas of the liver, and a few hepatocellular carcinomas were seen. Treatment with nitrosopyrrolidine lasted 50 weeks and the first animal in the group died at the 63rd week with an hepatocellular carcinoma. By the 110th week, almost all of these animals had died with the same type of tumor, and the 2 survivors were then killed. Many of the hepatocellular carcinomas had metastasized. There were no tumors of the liver in the rats treated with nitrosopiperidine.
将三种同源环状亚硝胺——亚硝基吡咯烷、亚硝基哌啶和亚硝基六亚甲基亚胺，以0.9 mM溶液的形式添加到饮用水中，分别给予20只雌性F344大鼠饮用。用后两种化合物进行的处理持续28周，此时有几只动物死于食管肿瘤。在实验的第36周时，这两组中的所有动物均已死亡。大多数给予亚硝基六亚甲基亚胺的动物还患有肝脏血管肉瘤，并且可见少数肝细胞癌。用亚硝基吡咯烷进行的处理持续50周，该组中的第一只动物在第63周时死于肝细胞癌。到第110周时，几乎所有这些动物均死于同一类型的肿瘤，随后处死了2只存活的动物。许多肝细胞癌已发生转移。用亚硝基哌啶处理的大鼠未出现肝脏肿瘤。
