给叙利亚金黄地鼠饮用含有低剂量亚硝基吡咯烷的水所产生的致癌作用。
Carcinogenic effect of low doses of nitrosopyrrolidine administered in drinking water to Syrian golden hamsters.
作者信息
Ketkar M B, Schneider P, Preussmann R, Plass Ch, Mohr U
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):75-9. doi: 10.1007/BF00402055.
Abstract
Three groups of Syrian golden hamsters each consisting of 30 males and 30 females were given three different doses of nitrosopyrrolidine in their drinking water for the duration of their lives. The animals mainly showed hepatocellular neoplasms. Males were more affected than females and tumor incidence was found to be dose-dependent. No liver tumors were seen in females that received the lowest dose.
摘要
三组叙利亚金黄地鼠，每组由30只雄性和30只雌性组成，在其一生中饮用含有三种不同剂量亚硝基吡咯烷的水。这些动物主要表现为肝细胞肿瘤。雄性比雌性受影响更严重，且肿瘤发生率呈剂量依赖性。接受最低剂量的雌性未出现肝肿瘤。
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2
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3
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