Waddington G, Banks P
J Neurochem. 1981 Sep;37(3):576-81. doi: 10.1111/j.1471-4159.1982.tb12525.x.
Evidence based on the ability to accumulate [3H]noradrenaline by a mechanism sensitive to desmethylimipramine suggests that there is a period of hyperinnervation of the cerebellum by noradrenergic fibres around the beginning of the second postnatal week. Different developmental profiles for specific noradrenaline uptake and noradrenaline content indicate that invasion of the tissue by noradrenergic fibres precedes their full acquisition of transmitter. Developmental increases in the density of beta-receptors and adenyl cyclase responsiveness to isoproterenol lags behind those of the presynaptic components and does not begin until the hyperinnervation is declining around day 12.
基于通过对去甲丙咪嗪敏感的机制积累[3H]去甲肾上腺素的能力所获得的证据表明，在出生后第二周开始时，去甲肾上腺素能纤维对小脑存在一段超神经支配期。特定去甲肾上腺素摄取和去甲肾上腺素含量的不同发育模式表明，去甲肾上腺素能纤维侵入组织先于它们完全获得递质。β受体密度和腺苷酸环化酶对异丙肾上腺素反应性的发育性增加落后于突触前成分，并且直到第12天左右超神经支配开始下降时才开始。
