Waddington G, Bower A J, Banks P
J Neurochem. 1982 Jun;38(6):1588-92. doi: 10.1111/j.1471-4159.1982.tb06637.x.
A newly developed method for cutting the cerebellar peduncles in neonatal rats has allowed the study of the development of cerebellar beta-adrenergic receptors in the absence of noradrenergic afferents. Cutting the cerebellar peduncles of neonatal animals did not affect the pattern of development of the beta-adrenergic receptors, nor their final numbers. Pedunclectomy induced a decline in the ability of slices of cerebellar cortex to accumulate [3H]noradrenaline although high-affinity noradrenaline uptake, was never completely abolished. It is suggested that the remaining high-affinity noradrenaline uptake cannot be attributed to noradrenergic fibres from the locus coeruleus.
一种新开发的切断新生大鼠小脑脚的方法，使得在没有去甲肾上腺素能传入神经的情况下研究小脑β-肾上腺素能受体的发育成为可能。切断新生动物的小脑脚并不影响β-肾上腺素能受体的发育模式，也不影响其最终数量。小脑脚切断术导致小脑皮质切片积累[3H]去甲肾上腺素的能力下降，尽管高亲和力的去甲肾上腺素摄取从未完全消除。有人认为，剩余的高亲和力去甲肾上腺素摄取不能归因于来自蓝斑的去甲肾上腺素能纤维。
