犬肾（Na +，K +）-ATP酶比人红细胞（Na +，K +）-ATP酶对钒酸盐抑制更敏感。

Dog kidney (Na+,K+)-ATPase is more sensitive to inhibition by vanadate than human red cell (Na+,K+)-ATPase.

作者信息

Bond G H, Hudgins P M

出版信息

Biochim Biophys Acta. 1981 Sep 7;646(3):479-82. doi: 10.1016/0005-2736(81)90318-7.

Abstract

(Na+,K+)-ATPase (EC 3.6.1.3) from kidney is more sensitive to inhibition by vanadate than red cell (Na+,K+)-ATPase. The difference appears to be in the apparent affinities of the two enzymes for K+ and Na+ at sites where K+ promotes and Na+ opposes vanadate binding. As a result of Na+-K+ competition at these sites, reversal of vanadate inhibition was accomplished at lower Na+ concentrations in red cell than in kidney (NA+,K+)-ATPase. It is possible that vanadate could selectively regulate Na+ transport in the kidney.

摘要

肾脏中的（钠，钾）-ATP酶（EC 3.6.1.3）比红细胞中的（钠，钾）-ATP酶对钒酸盐抑制作用更敏感。这种差异似乎在于两种酶在钾促进和钠抑制钒酸盐结合的位点对钾和钠的表观亲和力。由于这些位点存在钠钾竞争，红细胞中钒酸盐抑制作用的逆转在比肾脏（钠，钾）-ATP酶更低的钠浓度下即可完成。钒酸盐有可能选择性地调节肾脏中的钠转运。