Puschendorf B, Grunicke H, Jentsch J, Berger H
J Clin Chem Clin Biochem. 1981 Sep;19(9):979-81.
The present study shows an increased urinary cyclic guanosine 3'.5'-monophosphate (cyclic GMP) excretion rate in children of all age groups bearing malignant tumours or lymphomas. The incidence of increased cyclic GMP excretion was highly significant (79%). Follow-up studies of up to three years have revealed that during periods of remission of malignant disease the urinary cyclic GMP excretion drops to near normal values, whereas recurrences are accompanied by a new increase of cyclic GMP excretion.
本研究表明，所有年龄段患有恶性肿瘤或淋巴瘤的儿童尿中环磷酸鸟苷（cGMP）排泄率均升高。cGMP排泄增加的发生率非常显著（79%）。长达三年的随访研究显示，在恶性疾病缓解期，尿cGMP排泄降至接近正常水平，而复发时cGMP排泄会再次增加。
