Ruff S J, Bauer J E, Keenan E J, Moseley H S, Fletcher W S
J Surg Oncol. 1981;18(1):55-9. doi: 10.1002/jso.2930180109.
It is well established that approximately 60% of female breast cancers contain estrogen receptors (ER+). The hormonal receptor status of male breast cancers remains relatively unknown. Tumor tissue from 14 patients has been reviewed at the University of Oregon Health Sciences Center. Specimens of all 14 patients were ER+ with a range of 5.5 to 374 fmol/mg protein. Eight of 12 patients had tumors which also contained progesterone receptors (PR+) with a range of 42 to 1852 fmol/mg protein. Nine patients were treated by modified radical mastectomy, two by radical mastectomy, one by simple mastectomy, and two by biopsies only. Twelve patients remain free of disease with a mean follow-up of less than 2 years. The two patients who developed metastases both responded to endocrine ablation by orchiectomy and subsequent adrenalectomy. These data suggest that male breast cancer is highly endocrine sensitive and that endocrine ablation can play an integral part in those men unfortunate enough to develop disseminated disease.
众所周知，大约60%的女性乳腺癌含有雌激素受体（ER+）。男性乳腺癌的激素受体状态仍然相对未知。俄勒冈大学健康科学中心对14名患者的肿瘤组织进行了复查。所有14名患者的标本均为ER+，范围为5.5至374 fmol/mg蛋白质。12名患者中有8名的肿瘤还含有孕激素受体（PR+），范围为42至1852 fmol/mg蛋白质。9名患者接受了改良根治性乳房切除术，2名接受了根治性乳房切除术，1名接受了单纯乳房切除术，2名仅接受了活检。12名患者仍无疾病，平均随访时间不到2年。发生转移的两名患者对通过睾丸切除术和随后的肾上腺切除术进行的内分泌消融均有反应。这些数据表明，男性乳腺癌对内分泌高度敏感，内分泌消融在那些不幸发生播散性疾病的男性中可以发挥重要作用。
