Mohammed R H, Lakatua D J, Haus E, Yasmineh W J
Cancer. 1986 Sep 1;58(5):1076-81. doi: 10.1002/1097-0142(19860901)58:5<1076::aid-cncr2820580516>3.0.co;2-m.
Microscopic review of 490 consecutive human breast biopsy and mastectomy specimens were correlated with estrogen and progesterone receptor content of the tissue, by subtype and degree of differentiation. Of the 4 grades of differentiation, the less differentiated Grade III and IV tumors showed significantly lower levels of estrogen and progesterone receptors in infiltrating ductal and lobular carcinoma (P less than 0.001). In contrast, patients with medullary carcinoma had the lowest tissue levels of estrogen and progesterone receptors with approximately 80% of the cases with less than 10 fmol/mg protein. Patients with mucinous carcinoma had the highest percentages of positive estrogen and progesterone receptor levels (75% and 87%, respectively). Sixty-three percent of the patients with Grade IV infiltrating ductal carcinoma were younger than 53 years of age (P less than 0.001). Patients younger than 53 years of age with Grade II and III infiltrating ductal carcinoma also had significantly lower levels of estrogen receptors, but not of progesterone receptors, than those patients older than 53 years of age (P less than 0.001). Nineteen of 20 "normal" breast tissue specimens were negative (less than 3 fmol/mg protein) for estrogen and progesterone receptors. About 50% of 17 tissue specimens from benign breast lesions (fibroadenoma, fibrocystic disease, sclerosing adenosis) showed positive estrogen (greater than 10 fmol/mg protein) or progesterone receptor values. In two patients with gynecomastia, no estrogen or progesterone receptors were detectable.
对490例连续的人乳腺活检和乳房切除术标本进行显微镜检查，并根据组织的亚型和分化程度，将其与雌激素和孕激素受体含量相关联。在4个分化等级中，分化程度较低的III级和IV级肿瘤在浸润性导管癌和小叶癌中显示出显著较低的雌激素和孕激素受体水平（P<0.001）。相比之下，髓样癌患者的雌激素和孕激素受体组织水平最低，约80%的病例蛋白含量低于10 fmol/mg。黏液癌患者的雌激素和孕激素受体阳性率最高（分别为75%和87%）。IV级浸润性导管癌患者中有63%年龄小于53岁（P<0.001）。年龄小于53岁的II级和III级浸润性导管癌患者的雌激素受体水平也显著低于年龄大于53岁的患者，但孕激素受体水平并非如此（P<0.001）。20例“正常”乳腺组织标本中有19例雌激素和孕激素受体呈阴性（蛋白含量低于3 fmol/mg）。17例良性乳腺病变（纤维腺瘤、纤维囊性疾病、硬化性腺病）组织标本中约50%显示雌激素（蛋白含量大于10 fmol/mg）或孕激素受体值为阳性。在两名男性乳房发育患者中，未检测到雌激素或孕激素受体。
