男性乳腺癌患者的性激素谱。
The sex hormone profile of male patients with breast cancer.
作者信息
Nirmul D, Pegoraro R J, Jialal I, Naidoo C, Joubert S M
出版信息
Br J Cancer. 1983 Sep;48(3):423-7. doi: 10.1038/bjc.1983.208.
Abstract
The mean total serum oestradiol level was found to be significantly increased in 8 patients with carcinoma of the breast when compared with 8 healthy reference subjects matched for race, sex and age. The calculated mean free oestradiol index was also higher in these patients. There were no significant differences, however, between the levels of LH, FSH, prolactin. DHEA-S, testosterone and SHGB in the 2 groups. The patients showed a significantly increased LH response to GnRH while there was no difference in the FSH response. Only 1/7 patients had a tumour devoid of steroid hormone receptors. It may be that an increased level of circulating oestradiol-17 beta is an important factor in the aetiology of hormone-dependent male breast cancer.
摘要
与8名年龄、性别和种族匹配的健康对照者相比，8例乳腺癌患者的血清总雌二醇水平显著升高。这些患者计算得出的游离雌二醇指数也更高。然而，两组间LH、FSH、催乳素、脱氢表雄酮硫酸盐、睾酮和性激素结合球蛋白水平无显著差异。患者对促性腺激素释放激素（GnRH）的LH反应显著增加，而FSH反应无差异。7例患者中仅1例肿瘤缺乏类固醇激素受体。循环中17-β雌二醇水平升高可能是激素依赖性男性乳腺癌病因中的一个重要因素。
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