97Ru-DMSA for delayed renal imaging.

Dimercaptosuccinic acid (DMSA) was labeled with 97Ru both with and without the addition of SnCl.2H2O. The tin-containing preparation was found to induce higher cortical deposition of 97Ru-DMSA than the tin-free preparation. Visualization of the renal cortex was excellent 4 to 48 hours after injection in normal dogs with renal insufficiency. It is concluded that 97Ru-(Sn+2)-DMSA is a potentially useful renal imaging agent when delayed scintigraphy is necessary because of decompensaton of the kidneys.