Murayama T, Yamada T, Taguchi H, Watanabe Y, Tasei Y
Hinyokika Kiyo. 1983 Nov;29(11):1463-8.
To establish a method of detecting divided renal function of the obstructed kidneys noninvasively, comparative studies on 99mTc -DMSA uptake (60 minutes after injection), I 131-hippuran renal uptake (1-2 minutes after injection) and divided creatinine clearance immediately after relief of urinary obstruction were made on 24 cases of obstructive uropathy. A close significant correlation was obtained between 99mTc -DMSA and I 131-hippuran renal uptakes (gamma = 0.8809, P less than 0.001). Also, a significant correlation was noted between 99mTc -DMSA renal uptake and divided creatinine clearance (gamma = 0.7876, P less than 0.001), but the latter constantly gave lower values than the former. These observations led us to conclude that 99mTc -DMSA renal uptake is a reliable indicator of the renal plasma flow in the obstructed kidneys. Quantitative divided renal function of the obstructed kidneys can be estimated by the 99mTc -DMSA uptake method.
为建立一种无创检测梗阻性肾脏分肾功能的方法，对24例梗阻性尿路病患者进行了99mTc -二巯基丁二酸（99mTc -DMSA）摄取（注射后60分钟）、碘131-马尿酸肾摄取（注射后1 - 2分钟）以及尿路梗阻解除后即刻分肾功能肌酐清除率的对比研究。99mTc -DMSA与碘131-马尿酸肾摄取之间存在密切显著相关性（γ = 0.8809，P < 0.001）。此外，99mTc -DMSA肾摄取与分肾功能肌酐清除率之间也存在显著相关性（γ = 0.7876，P < 0.001），但后者的值始终低于前者。这些观察结果使我们得出结论，99mTc -DMSA肾摄取是梗阻性肾脏肾血浆流量的可靠指标。梗阻性肾脏的定量分肾功能可通过99mTc -DMSA摄取法进行评估。
