Dumitriu L, Stefăneanu L, Taşcă C
Endocrinologie. 1981 Jan-Mar;19(1):39-43.
Authors studied ten cases of folliculo-papillary thyroid carcinoma, using ultrastructural methods and cytochemical techniques for peroxidase and acid phosphatase activities. The most striking ultrastructural features were: disappearance of secretory granules or apical vesicles; nuclei with an irregular shape containing stage I and II inclusions; two types of cells: with dilate endoplasmic sacks filled with a granular material, or rich in closely packed mitochondria, some of them showing dystrophic lesions with round, dense bodies or tightly packed parallel filaments and numerous phagolysosomes. The peroxidase activity was present as black DAB precipitates in the nuclear envelope and sometimes around colloid droplets, or was completely absent from some cells. The acid phosphatase activity was found as unhomogeneous Pb precipitates inside the lysosomes. The ultrastructural and cytoenzymological pattern suggests marked alteration of the synthesis, storage and secretion of the thyroid hormones. Keeping in mind that results of radio-iodine treatment depend mainly on the histologic type of the thyroid carcinoma, the cooperation between radiotherapeutist and pathologist is emphasized.
作者使用超微结构方法以及过氧化物酶和酸性磷酸酶活性的细胞化学技术，研究了10例滤泡乳头状甲状腺癌。最显著的超微结构特征为：分泌颗粒或顶端小泡消失；细胞核形状不规则，含有I期和II期包涵体；两种类型的细胞：一种细胞内质网囊扩张，充满颗粒物质，另一种细胞富含紧密排列的线粒体，其中一些线粒体显示出营养不良性病变，有圆形致密体或紧密排列的平行细丝以及大量吞噬溶酶体。过氧化物酶活性表现为在核膜中以及有时在胶体滴周围出现黑色DAB沉淀，或者在一些细胞中完全缺失。酸性磷酸酶活性表现为溶酶体内不均匀的铅沉淀。超微结构和细胞酶学模式表明甲状腺激素的合成、储存和分泌发生了显著改变。鉴于放射性碘治疗的结果主要取决于甲状腺癌的组织学类型，强调了放疗科医生和病理科医生之间的合作。
