Taşcă C, Stefăneanu L
Morphol Embryol (Bucur). 1981 Jul-Sep;27(3):239-44.
Twenty cases of thyroid carcinoma (10 follicular and 10 folliculo-papillary) were ultrastructurally studied. In the follicular carcinoma the most striking features were: microfollicular cavities with microvilli from the apical surface of the tumorous cells, intracellular microlumens, swollen mitochondria sometimes containing electrondense bodies and tightly packed filaments. In the solid sheaths light and dark cells were present. Golgi complexes were disposed in small dense cristae. The nuclei were large, round, oval or with a folded appearance. In the folliculo-papillary carcinoma were found nuclei with an irregular shape containing stage I and stage II inclusions, dilated endoplasmic sacks, closely packed, sometimes dystrophic mitochondria, dense bodies or tightly packed parallel filaments and numerous phagolysosomes. The peroxidase activity wa present as black precipitates in the nuclear envelope or around colloid droplets. The acid phosphatase activity was found as unhomogeneous precipitates inside the lysosomes. From this study it could be concluded that the follicular and folliculo-papillary carcinomas have some common ultrastructural features; the ultrastructural and cytoenzymological patterns suggest marked alteration of the synthesis, storage and secretion of thyroid hormones.
对20例甲状腺癌（10例滤泡状癌和10例滤泡乳头状癌）进行了超微结构研究。在滤泡状癌中，最显著的特征是：肿瘤细胞顶端表面有微绒毛的微滤泡腔、细胞内微腔、有时含有电子致密体的肿胀线粒体以及紧密排列的细丝。在实性包膜中存在亮细胞和暗细胞。高尔基体复合体分布在小而致密的嵴中。细胞核大，呈圆形、椭圆形或有折叠外观。在滤泡乳头状癌中，发现细胞核形状不规则，含有I期和II期包涵体、扩张的内质网囊、紧密排列、有时营养不良的线粒体、致密体或紧密排列的平行细丝以及大量吞噬溶酶体。过氧化物酶活性以黑色沉淀形式出现在核膜或胶体滴周围。酸性磷酸酶活性表现为溶酶体内不均匀的沉淀。从这项研究可以得出结论，滤泡状癌和滤泡乳头状癌有一些共同的超微结构特征；超微结构和细胞酶学模式表明甲状腺激素的合成、储存和分泌有明显改变。
