泼尼松龙三周疗程后血浆促肾上腺皮质激素和皮质醇水平的恢复情况。
Recovery of plasma corticotrophin and cortisol levels after three-week course of prednisolone.
作者信息
Webb J, Clark T J
出版信息
Thorax. 1981 Jan;36(1):22-4. doi: 10.1136/thx.36.1.22.
Abstract
Patients with chronic airflow obstruction were given a three-week course of prednisolone 40 mg per day. The basal plasma cortisol level and response to tetracosactrin were depressed after such a course. Basal plasma cortisol and corticotrophin (ACTH) levels were measured on five consecutive days after three weeks of treatment with prednisolone and were found to rise simultaneously to control levels within three days. Pituitary and adrenal functions were depressed for four days after short high dose courses of corticosteroids and patients may be at risk if they encounter stress during this time.
摘要
患有慢性气流阻塞的患者接受了为期三周的每日40毫克泼尼松龙治疗。经过这样一个疗程后，基础血浆皮质醇水平和对二十四肽促皮质素的反应均降低。在使用泼尼松龙治疗三周后的连续五天测量基础血浆皮质醇和促肾上腺皮质激素（ACTH）水平，发现它们在三天内同时升至对照水平。短期高剂量皮质类固醇疗程后，垂体和肾上腺功能会在四天内受到抑制，如果患者在此期间遭遇压力，可能会面临风险。
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