Confer A W, Enright F M, Beard G B
Vet Pathol. 1981 Nov;18(6):738-44. doi: 10.1177/030098588101800604.
A subcutaneous extraskeletal giant cell tumor (malignant fibrous histiocytoma) was excised repeatedly from a 9-year-old Domestic Shorthair cat. Ultrastructurally, the mass was composed of fibroblast-like, histiocyte-like, and multinucleated giant cells, and some undifferentiated cells and mononuclear cells intermediate between the fibroblast-like and histiocyte-like cells. Fibroblast-like cells were characterized by abundant well-developed rough endoplasmic reticulum, relatively smooth cytoplasmic membranes, few lysosomal structures, and finely granular chromatin. Histiocyte-like cells resembled immature macrophages. The cell membranes had many villous projections. Rough endoplasmic reticulum varied in quantity. Lysosomes were numerous. Multinucleated giant cells had characteristics of both the fibroblast-like and histiocyte-like cells. No viral particles were seen.
从一只9岁的家养短毛猫身上反复切除了一个皮下骨外巨细胞瘤（恶性纤维组织细胞瘤）。超微结构上，肿块由成纤维细胞样、组织细胞样和多核巨细胞组成，还有一些未分化细胞以及介于成纤维细胞样和组织细胞样细胞之间的单核细胞。成纤维细胞样细胞的特征是有丰富发达的粗面内质网、相对光滑的细胞质膜、较少的溶酶体结构以及细颗粒状染色质。组织细胞样细胞类似于未成熟的巨噬细胞。细胞膜有许多绒毛状突起。粗面内质网数量不一。溶酶体众多。多核巨细胞具有成纤维细胞样和组织细胞样细胞的特征。未见病毒颗粒。
