Yamate J, Tajima M, Shibuya K, Ihara M, Kudow S
Nihon Juigaku Zasshi. 1989 Jun;51(3):587-96. doi: 10.1292/jvms1939.51.587.
Malignant fibrous histiocytoma (MFH) developed spontaneously in subcutaneous tissue of the head of a 15-month-old male Fischer 344 rat. The tumor was serially transplanted into syngeneic rats up to the 45th generation and was designated MFH-MT. Light and electron microscopic examinations revealed that the original and serially transplanted tumors were composed of an admixture of fibroblast-like and histiocyte-like cells arranged in a storiform pattern. Neoplastic cells gave positive reactions for acid phosphatase, alkaline phosphatase, nonspecific esterase, alpha-1 antitrypsin and lysozyme. The tumors transplanted into the lungs and cutaneous tissue of the tail had a mixed histologic appearance of storiform, pleomorphic, myxoid and giant cell types. Moreover sclerosing hemangioma-like and osteosarcoma-like structures were also found. MFH-MT grew well in athymic nude mice showing neoplastic proliferation of pleomorphic cells strongly positive for alpha-1 antitrypsin. Development of MFH-MT was significantly retarded by the two antitumor drugs tested. The retarded tumors consisted predominantly of fibroblast-like cells and abundant collagenic fibers, whereas histiocytic cells decreased in number.
一只15个月大的雄性Fischer 344大鼠头部皮下组织自发形成恶性纤维组织细胞瘤（MFH）。该肿瘤连续移植至同基因大鼠达第45代，并命名为MFH-MT。光镜和电镜检查显示，原发肿瘤及连续移植的肿瘤均由呈束状排列的成纤维细胞样和组织细胞样细胞混合组成。肿瘤细胞对酸性磷酸酶、碱性磷酸酶、非特异性酯酶、α-1抗胰蛋白酶和溶菌酶呈阳性反应。移植到肺部和尾部皮肤组织的肿瘤具有束状、多形性、黏液样和巨细胞型的混合组织学表现。此外，还发现了硬化性血管瘤样和骨肉瘤样结构。MFH-MT在无胸腺裸鼠中生长良好，显示出对α-1抗胰蛋白酶呈强阳性的多形性细胞的肿瘤性增殖。所测试的两种抗肿瘤药物显著抑制了MFH-MT的生长。生长受抑制的肿瘤主要由成纤维细胞样细胞和丰富的胶原纤维组成，而组织细胞数量减少。
