Lamke B, Björkholm E
Acta Radiol Oncol. 1981;20(2):109-11. doi: 10.3109/02841868109130429.
Bone mineral content after treatment for malignant gynaecologic tumours was examined in women of fertile age. The treatment given was intracavitary radium applications followed by bilateral oophorectomy. In women who received oestrogen substitution the bone mineral content increased by one per cent a year, whereas nonsubstituted women lost 3 per cent of their initial bone mineral content per year. The findings suggest that oestrogen deficiency is the predominant cause of bone mineral loss initiated by this therapy.
对育龄期女性恶性妇科肿瘤治疗后的骨矿物质含量进行了检查。所采用的治疗方法是腔内镭敷贴，随后进行双侧卵巢切除术。接受雌激素替代治疗的女性，其骨矿物质含量每年增加1%，而未接受替代治疗的女性每年则损失其初始骨矿物质含量的3%。这些研究结果表明，雌激素缺乏是该治疗引发骨矿物质流失的主要原因。
