Toivanen A, Nordman E
Acta Radiol Oncol. 1981;20(2):119-24. doi: 10.3109/02841868109130431.
The effect of postoperative irradiation on the immune functions of 13 patients with breast carcinoma is reported, using as parameters the peripheral blood lymphocyte count, percentages of E and EAC rosette forming cells, and lymphocyte proliferative responses to PHA, Con A and PPD. After irradiation the number of peripheral blood lymphocytes was reduced during 8 months. The percentages of E and EAC rosette forming cells were not altered during the observation time of 7 to 36 months. In the proliferative responses of lymphocytes to PHA, Con A and PPD, the postoperative irradiation caused a decrease which, regarding PHA and Con A, lasted up to 8 months and then recovered. The decrease in the proliferative responses to PPD was stronger and lasted during the whole observation time. In the mitogenic responses of patients with recurrent or disseminating disease no difference could be demonstrated as compared with the patients living recurrence-free.
报道了术后放疗对13例乳腺癌患者免疫功能的影响，采用外周血淋巴细胞计数、E和EAC玫瑰花结形成细胞百分比以及淋巴细胞对PHA、Con A和PPD的增殖反应作为参数。放疗后8个月外周血淋巴细胞数量减少。在7至36个月的观察期内，E和EAC玫瑰花结形成细胞百分比未改变。在淋巴细胞对PHA、Con A和PPD的增殖反应中，术后放疗导致下降，就PHA和Con A而言，这种下降持续长达8个月，然后恢复。对PPD增殖反应的下降更强，且在整个观察期内持续存在。与无复发患者相比，复发或播散性疾病患者的促有丝分裂反应无差异。
