Nordman E, Saarimaa H, Toivanen A
Cancer. 1978 Jan;41(1):64-9. doi: 10.1002/1097-0142(197801)41:1<64::aid-cncr2820410111>3.0.co;2-4.
The effects of 5-fluorouracil (5-FU) on the immune functions of twelve patients with disseminated cancer were studied, using as parameters the peripheral blood lymphocyte count, serum immunoglobulin levels, titers of natural blood group antibodies, percentages of E and EAC rosette forming cells, and lymphocyte proliferative responses to PHA and PPD. No effects on the humoral immune functions or on the percentages of E and EAC rosette forming cells were observed. 5-FU caused a decrease in the proliferative responses of lymphocytes to PHA and PPD. The patients could be divided into two groups: those surviving for six months or more, and those succumbing earlier. The latter ones had already initially poor proliferative responses, particularly to PPD, and the response strongly decreased during the 5-FU treatment. In the patients with a longer survival time, the effects of 5-FU on the PPD and PHA responses were not as striking.
研究了5-氟尿嘧啶（5-FU）对12例播散性癌症患者免疫功能的影响，采用外周血淋巴细胞计数、血清免疫球蛋白水平、天然血型抗体滴度、E和EAC玫瑰花结形成细胞百分比以及淋巴细胞对PHA和PPD的增殖反应作为参数。未观察到对体液免疫功能或E和EAC玫瑰花结形成细胞百分比的影响。5-FU导致淋巴细胞对PHA和PPD的增殖反应降低。患者可分为两组：存活6个月或更长时间的患者，以及较早死亡的患者。后者最初的增殖反应就很差，尤其是对PPD的反应，并且在5-FU治疗期间反应强烈降低。在存活时间较长的患者中，5-FU对PPD和PHA反应的影响不那么显著。
