Invasive squamous cell carcinoma of the uterine cervix. II. Reproducibility of a histopathologic malignancy grading system.

A histopathologic malignancy grading system for invasive squamous carcinoma of the uterine cervix has previously been presented. The grading results in a total malignancy point value for every patient (range 8-24). This score has been proven to have a significant prognostic value for the individual patient. The inter-observer reproducibility of this system has been examined by two pathologists, on the pretreatment biopsies of 100 patients and the intra-observer reproducibility on 190 patients (observer one) and on 100 patients (observer two). These biopsies were estimated twice and three times, respectively, without knowledge of former results and at an interval of 2 to 6 months. The inter-observer correlation coefficient was 0.54, the intra-observer correlation coefficients 0.94 and 0.74, respectively.