Schnekenburger J
Arzneimittelforschung. 1981;31(8):1286-90.
With an automated method, four antacid gel formulations were tested for antacid in vitro activity. In addition, some elements involved in the buffer effect were assayed in the solution parallel to the in vitro test. Of the four formulations, one showed only insufficient buffer effect. Compared with the common proton/metal ion exchange of antacid buffering, experimental data of another formulation suggest a partially different proton binding mechanism.
采用自动化方法对四种抗酸凝胶制剂进行了体外抗酸活性测试。此外，在与体外试验平行的溶液中测定了缓冲作用涉及的一些元素。在这四种制剂中，有一种仅表现出不足的缓冲效果。与抗酸缓冲常见的质子/金属离子交换相比，另一种制剂的实验数据表明存在部分不同的质子结合机制。
