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人绒毛膜促性腺激素对兔子宫内膜蛋白激酶的调节作用。

Regulation by human chorionic gonadotropin of protein kinases in rabbit endometrium.

作者信息

Miyazaki K, Matsui K, Maeyama M, Miyamoto E

出版信息

Biochim Biophys Acta. 1981 Sep 18;677(1):120-5. doi: 10.1016/0304-4165(81)90152-5.

DOI:10.1016/0304-4165(81)90152-5
PMID:6271246
Abstract

The effect of human chorionic gonadotropin (CG) on protein kinase levels has been studied in rabbit endometrium. A good correlation was observed between alterations of total protein kinase activity and DNA content in the tissue. The level of type I cyclic AMP-dependent protein kinase had slightly increased by 6 h after human CG treatment, and then decreased later. In contrast, the type II enzyme gradually increased after 3 days. The increase of the activity at 7 days was mainly due to that of type II enzyme, and the ratio of type II to type I enzyme increased. The activity pattern at the later stage closely resembled that of treatment with progesterone.

摘要

在兔子宫内膜中研究了人绒毛膜促性腺激素(CG)对蛋白激酶水平的影响。观察到组织中总蛋白激酶活性的变化与DNA含量之间存在良好的相关性。人CG处理后6小时,I型环磷酸腺苷依赖性蛋白激酶水平略有升高,随后下降。相比之下,II型酶在3天后逐渐增加。7天时活性的增加主要归因于II型酶,且II型与I型酶的比例增加。后期的活性模式与孕酮处理的模式非常相似。

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