Kruse H P, Kuhlencordt F, Ringe J D
Dtsch Med Wochenschr. 1978 Feb 10;103(6):248-52. doi: 10.1055/s-0028-1104416.
Twenty-three patients with primary osteoporosis were treated with sodium fluoride over 25 months. Mean total dose was 21 g fluoride. Symptoms, body size, biochemical results, radiological changes and skeletal mineral content as well as bone histomorphometry were evaluated in assessing results of treatment. Accordingly, no advance in the disease process was demonstrable in 13 patients, while there was definite improvement in six, but in four there was further progression.
23例原发性骨质疏松患者接受了25个月的氟化钠治疗。平均总剂量为21克氟化物。在评估治疗效果时，对症状、体型、生化结果、放射学变化、骨骼矿物质含量以及骨组织形态计量学进行了评估。因此，13例患者的疾病进程没有进展，6例有明显改善，但4例病情进一步发展。
