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用新型缓释氟化钠制剂治疗骨质疏松症(作者译)

[Treatment of osteoporosis with a new retard-preparation of sodium fluoride (author's transl)].

作者信息

Tausch G, Petera P, Bröll H, Eberl R, Falkensamer C, Fischer M

出版信息

Wien Med Wochenschr. 1979 May 15;129(9):251-4.

PMID:442686
Abstract

25 female patients with different forms of osteoporosis (progredient form in elderly patients, steroid osteoporosis, involutive osteoporosis) treated during a period varying between 1 to 24 months with a new compound preparation containing 25 mg sodium fluoride and 200 mg L-ascorbic acid per tablet. The daily dose amounts to 2 tablets. Clinical success was observed in 18 patients, X-ray controls showed increase of bone density in 8 patients. In 3 cases it was necessary to discontinue treatment because of side effects (2 patients with pains in the bones and joints, 1 patient with stomach troubles). Late side effects have not been observed. At present the treatment of certain forms of osteoporosis with sodium fluoride is the only effective therapy of this disease.

摘要

25名患有不同类型骨质疏松症(老年患者的进行性骨质疏松症、类固醇性骨质疏松症、绝经后骨质疏松症)的女性患者,接受了一种新的复方制剂治疗,疗程为1至24个月。该复方制剂每片含25毫克氟化钠和200毫克L-抗坏血酸。每日剂量为2片。18名患者取得了临床成功,X线检查显示8名患者骨密度增加。3例因副作用而停药(2例骨骼和关节疼痛,1例胃部不适)。未观察到晚期副作用。目前,用氟化钠治疗某些类型的骨质疏松症是该病唯一有效的疗法。

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1
[Treatment of osteoporosis with a new retard-preparation of sodium fluoride (author's transl)].用新型缓释氟化钠制剂治疗骨质疏松症(作者译)
Wien Med Wochenschr. 1979 May 15;129(9):251-4.
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Sodium fluoride in the treatment of osteoporosis.
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