Turkanis S A, Karler R
J Clin Pharmacol. 1981 Aug-Sep;21(S1):449S-463S. doi: 10.1002/j.1552-4604.1981.tb02625.x.
The effects of the psychoactive cannabinoid delta 9-tetrahydrocannabinol (THC) and the nonpsychoactive cannabinoid cannabidiol (CBD) were investigated comparatively on electrically caused transcallosal cortical evoked responses, electrically induced limbic after discharges, photically evoked cortical afterdischarges, spontaneous cortical focal epileptic potentials, and spinal monosynaptic reflexes. In each system, THC produced central excitation; for example, the drug's responses ranged from enhancement of synaptic transmission to precipitation of frank convulsions. In addition to central nervous system stimulation, THC usually elicited depression; the qualitative character of the effect of the drug was dependent upon the dosage and the test system. In contrast to THC, cannabidiol generated no CNS excitation: it was either depressant or inert in these test systems. The results clearly demonstrate the complexity of the CNS properties of THC and the selectivity of the depressant properties of cannabidiol; moreover, the data illustrate the wide range of neuropharmacologic responses that potentially any cannabinoid can effect.
对精神活性大麻素Δ9 - 四氢大麻酚（THC）和非精神活性大麻素大麻二酚（CBD），就电刺激引起的胼胝体皮质诱发反应、电诱导的边缘叶后放电、光刺激诱发的皮质后放电、自发性皮质局灶性癫痫电位以及脊髓单突触反射进行了比较研究。在每个系统中，THC均产生中枢兴奋；例如，该药物的反应范围从突触传递增强到明显惊厥的发作。除中枢神经系统刺激外，THC通常还引起抑制；药物作用的定性特征取决于剂量和测试系统。与THC相反，大麻二酚未产生中枢神经系统兴奋：在这些测试系统中它要么具有抑制作用，要么无活性。结果清楚地表明了THC中枢神经系统特性的复杂性以及大麻二酚抑制特性的选择性；此外，数据说明了任何大麻素都可能产生的广泛神经药理反应。
