Turkanis S A, Karler R
Life Sci. 1983 Apr 11;32(15):1675-81. doi: 10.1016/0024-3205(83)90828-7.
Two barbiturates, pentobarbital and methohexital, were used as general anesthetics to evaluate their interactions with the effects of delta-9-tetrahydrocannabinol (delta-9-THC) on spinal monosynaptic reflexes in cats with transected spinal cords and ischemically destroyed brains. In animals initially anesthetized with pentobarbital, delta-9-THC over a wide dosage range produced only an enhancement of the reflex, whereas in methohexital-treated animals only depression was elicited. Because delta-9-THC is known to produce both excitatory and depressant effects in conscious animals, the results of the present study demonstrate that the choice of anesthetic may determine which effects manifest themselves. Therefore, if anesthesia is used in the investigation of any cannabinoid, the possibility of such interactions must be considered when interpreting the results.
两种巴比妥类药物，戊巴比妥和甲己炔巴比妥，被用作全身麻醉剂，以评估它们与δ-9-四氢大麻酚（δ-9-THC）对脊髓横断且大脑缺血性破坏的猫的脊髓单突触反射效应的相互作用。在最初用戊巴比妥麻醉的动物中，δ-9-THC在很宽的剂量范围内仅增强反射，而在甲己炔巴比妥处理的动物中仅引起反射抑制。由于已知δ-9-THC在清醒动物中会产生兴奋和抑制作用，本研究结果表明麻醉剂的选择可能决定哪些效应会显现出来。因此，如果在任何大麻素的研究中使用麻醉，在解释结果时必须考虑这种相互作用的可能性。
