Ogita S, Shimamoto T, Ohnishi M, Kamei T, Noma H, Ishiko O, Ando T, Sugawa T
Eur J Pediatr. 1978 Jan 17;127(2):67-73. doi: 10.1007/BF00445762.
Dynamic osmotic fragility of erythrocytes in cord blood and its changes during the neonatal period were studied by means of a coil planet centrifuge system. The starting-point for hemolysis in the newborn become similar to that of adult blood after approximately a week, while the shift of the end-point to the adult range required one month or more. The percentage of fragile cord blood cells with a hemolysis starting-point above 110 m osmol and the maximum bilirubin level during neonatal period were examined. A high percentage of fragile cells was associated with high bilirubin levels, and when fragile cells comprised more than 7.0% of the total cord blood erythrocytes, the bilirubin level tended to rise above 15 mg/dl.
采用盘管式行星离心机系统研究了脐血中红细胞的动态渗透脆性及其在新生儿期的变化。新生儿溶血的起始点在大约一周后变得与成人血液相似，而终点向成人范围的转变则需要一个月或更长时间。检测了溶血起始点高于110 m osmol的脐血脆性细胞百分比以及新生儿期的最高胆红素水平。高比例的脆性细胞与高胆红素水平相关，当脆性细胞占脐血红细胞总数的7.0%以上时，胆红素水平往往会升至15 mg/dl以上。
