人脑膜瘤中一种阶段特异性胚胎脑抗原的证实。
Demonstration of a phase (stage)-specific embryonic brain antigen in human meningioma.
作者信息
Kehayov I, Botev B, Vulchanov V, Kyurkchiev S
出版信息
Int J Cancer. 1976 Nov 15;18(5):587-92. doi: 10.1002/ijc.2910180507.
The water-soluble antigens of human embryonic brain were studied using a rabbit antiserum to human 8- to 10-week embryonic brain (non-absorbed and absorbed with extracts of human embryonic and adult organs). A phase (stage)-specific brain antigen(s) characteristic for the human 8- to 10-week-old embryo was detected by double immunodiffusion and immunoelectrophoresis in agarose gel. The testing of this anti-embryonic brain serum against saline extracts of human brain tumours (meningiomas, glioblastomas, astrocytomas, neurinomas and brain metastasis of carcinoma) revealed the presence of an "embryonic" antigen in the human meningioma only. Immunochemically this meningioma-associated antigen is identical to a phase (stage)-specific antigen of the 8- to 10-week embryo.
使用兔抗人8至10周胚胎脑血清（未吸收以及用人胚胎和成体器官提取物吸收后的血清）研究了人胚胎脑的水溶性抗原。通过琼脂糖凝胶中的双向免疫扩散和免疫电泳检测到一种对人8至10周龄胚胎具有特征性的阶段特异性脑抗原。用这种抗胚胎脑血清检测人脑肿瘤（脑膜瘤、胶质母细胞瘤、星形细胞瘤、神经鞘瘤和癌脑转移瘤）的盐水提取物，结果显示仅在人脑膜瘤中存在一种 “胚胎” 抗原。免疫化学分析表明，这种与脑膜瘤相关的抗原与8至10周胚胎的阶段特异性抗原相同。
Zotero 插件