甲硝唑在溶组织内阿米巴和阴道毛滴虫培养物中的代谢。
Metronidazole metabolism in cultures of Entamoeba histolytica and Trichomonas vaginalis.
作者信息
Beaulieu B B, McLafferty M A, Koch R L, Goldman P
出版信息
Antimicrob Agents Chemother. 1981 Sep;20(3):410-4. doi: 10.1128/AAC.20.3.410.
Abstract
Acetamide forms from metronidazole in cultures of either Entamoeba histolytica or Trichomonas vaginalis as it does in cultures of bacteria which are susceptible to this drug. Under aerobic conditions, the formation of acetamide is more rapid in a strain of T. vaginalis which is more susceptible to metronidazole. Thus, it appears that the formation of acetamide may be associated with the microbiocidal action of metronidazole.
摘要
在溶组织内阿米巴或阴道毛滴虫培养物中，甲硝唑会形成乙酰胺，就如同在对该药物敏感的细菌培养物中一样。在有氧条件下，对甲硝唑更敏感的阴道毛滴虫菌株中乙酰胺的形成更快。因此，乙酰胺的形成似乎可能与甲硝唑的杀菌作用有关。
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